Extracting Information from Cats by Jacobus H Jessurun

She recently saw her cardiologist and had some of her medications adjusted, but she canâ€™t remember what specific changes were made. She has a history of hypertension, congestive heart failure and an â€œirregular heartbeat.â€ She cannot remember what medications she takes. Propafenone Overdose-induced Arrhythmia and Subsequent Correction After Administration of Sodium Bicarbonateĭirectory of Open Access Journals (Sweden)įull Text Available History of present illness: 71-year old woman presented to the emergency department with near-syncope, chest pain, and shortness of breath. Propafenone is a class Ic anti-arrhythmic agent with mild B-blocking properties which has recently become available in South Africa. Normal left ventricular function does not protect against propafenone-induced incessant ventricular tachycardia.

Normal left ventricular function does not protect against propafenone. CONCLUSION: Propafenone had a depressing effect on the contractile function of latissimus dorsi muscle isolated from rats and studied in an organ chamber. In group II, a significant depression occurred in all periods, except between the last 2 periods (p0.05.

In comparison, insulin prevented the decline of MAP and heart rate, and the elongation of the PR interval and QRS duration for 55 minutes (P 0.05. Sodium bicarbonate prevented the decline of MAP for 55 minutes. Survival of the Insulin group was greater than that of the NSS group by log-rank test (P =. For each animal, the mean arterial pressure (MAP, heart rate, PR interval, QRS duration, total hemoglobin, sodium, potassium, potential of hydrogen, bicarbonate, glucose, lactate, and central venous oxygen saturation (Scvo2) were measured and compared among the groups. Animals in the NSS, NaHCO3, and Insulin groups received an intravenous infusion of 36 mg/(kg h) propafenone until death occurred. After the induction of toxicity, rats (n = 10 per group) received normal saline solution (NSS), NaHCO3, or insulin with glucose as treatment. Rats received intravenous propafenone (36 mg/) for 12 minutes. However, because the degree of effectiveness of insulin compared to the previously known antidote sodium bicarbonate (NaHCO3) was not studied, the 2 treatment methods were compared for propafenone intoxication in rats.

Yi et al recently studied insulin's treatment effect on acute propafenone toxicity in rats. Unlike other sodium-channel-blocking antiarrhythmic agents, propafenone has Î²-blocking effects and calcium-channel-blocking effects. Yi, Hwa Yeon Lee, Jang Young Lee, Won Suk Sung, Won Young Seo, Sang Won Comparison of the therapeutic effect between sodium bicarbonate and insulin on acute propafenone toxicity.

Extracting Information from Cats by Jacobus H Jessurun